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KMID : 0603520010060020098
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Journal of Korean Association of Cancer Prevention
2001 Volume.6 No. 2 p.98 ~ p.107
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Effect of a Formulated Cancer Preventive Diet and Its Dietary Restriction in Sarcoma-180 Cell Transplanted Mice
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Kim Su-Ok
Lee Sook-Hee
Park Kun-Young
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Abstract
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The effects of a formulated cancer preventive diet and its dietary restriction on tumor formation, natural killer (NK) cell activity, hepatic lipid peroxide content and glutathione S-transferase activity were investigated in sarcoma-180 cell
transplanted Balb/c mice. The formulated diet was prepared with cooked cereals, cooked legume, freeze-dried vegetables and seaweed, oil seeds, and fruit, and freeze-dried doenjang and kimchi. Total calorie of the formulated diet for the mice was designed to take 341 ㎉/100 g and the ratio of protein, fat and carbohydrate was 21%, 11% and 68%, respectively. Five week old male Balb/c mice were divided into 5 different groups: normal group, sarcoma-180 cell transplanted control group that fed with commercial chow diet ad libitum during experimental period, pre-treatment group that received tha formulated diet ad libitum for 8 weeks, co-treatment group that received the formulated diet ad libitum for 4 weeks followed by transplantation of sarcoma-180 cells, and dietary restriction group that was given 30% restriction of the formulated diet compared to the pre-treatment group for 8 weeks. At 4 weeks, all groups except normal group were transplanted with sarcoma-180 cells on the left groin of the mouse. The solid tumor growth in each group was inhibited by the treatment of the formulated diet. Especially, dietary restriction (30%) group resulted in the smallest tumor growth. The feeding of the formulated diet enhanced the NK cell activity of splenocyte, which was very low in normal and control group. Lipid peroxide content in the liver that increased by the injection of sarcoma-180 cells to the mice decreased significantly in the dietary restriction group. The effect of the diet restriction on hepatic glutathione S-transferase activity was higher than that of the other groups. These results suggest that the formulated diet has anticancer effect in vivo and the diet restriction even increases this activity.
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KEYWORD
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Sarcoma-180 cells, Formulated cancer preventive diet, Diet restriction
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